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Publikacje Projektowe

Targeting peroxiredoxin 1 impairs growth of breast cancer cells and potently sensitises these cells to prooxidant agents.

Bajor M, Zych AO, Graczyk-Jarzynka A, Muchowicz A, Firczuk M, Trzeciak L, Gaj P, Domagala A, Siernicka M, Zagozdzon A, Siedlecki P, Kniotek M, O'Leary PC, Golab J, Zagozdzon R.

Br J Cancer. 2018 Oct

https://www.ncbi.nlm.nih.gov/pubmed/30287919

 

Development of acquired resistance to lapatinib may sensitise HER2-positive breast cancer cells to apoptosis induction by obatoclax and TRAIL.

Eustace AJ, Conlon NT, McDermott MSJ, Browne BC, O'Leary P, Holmes FA, Espina V, Liotta LA, O'Shaughnessy J, Gallagher C, O'Driscoll L, Rani S, Madden SF, O'Brien NA, Ginther C, Slamon D, Walsh N, Gallagher WM, Zagozdzon R, Watson WR, O'Donovan N, Crown J.

BMC Cancer. 2018 Oct 11

https://www.ncbi.nlm.nih.gov/pubmed/30305055

 

Intraurethral co-transplantation of bone marrow mesenchymal stem cells and muscle-derived cells improves the urethral closure.

Burdzinska A, Dybowski B, Zarychta-Wiśniewska W, Kulesza A, Butrym M, Zagozdzon R, Graczyk-Jarzynka A, Radziszewski P, Gajewski Z, Paczek L.

Stem Cell Res Ther. 2018 Sep 21

https://www.ncbi.nlm.nih.gov/pubmed/30241573

 

Antitumor Activity of TLR7 Is Potentiated by CD200R Antibody Leading to Changes in the Tumor Microenvironment.

Pilch Z, Tonecka K, Braniewska A, Sas, Skorzynski M, Boon L, Golab J, Meyaard L, Rygiel TP.

Cancer Immunol Res. 2018 Aug

https://www.ncbi.nlm.nih.gov/pubmed/30021725

 

Typical and Atypical Inducers of Lysosomal Cell Death: A Promising Anticancer Strategy.

Domagala A, Fidyt K, Bobrowicz M, Stachura J, Szczygiel K, Firczuk M.

Int J Mol Sci. 2018 Aug 1

https://www.ncbi.nlm.nih.gov/pubmed/30071644

 

Outcomes of Prolonged Treatment With Intravenous Immunoglobulin Infusions for Acute Antibody-mediated Rejection in Kidney Transplant Recipients.

Bujnowska A, Michon M, Konopelski P, Hryniewiecka E, Jalbrzykowska A, Perkowska-Ptasinska A, Cieciura T, Zagozdzon R, Paczek L, Ciszek M.

Transplant Proc. 2018 Jul - Aug

https://www.ncbi.nlm.nih.gov/pubmed/29961551

 

Inhibition of protein disulfide isomerase induces differentiation of acute myeloid leukemia cells.

Chlebowska-Tuz J, Sokolowska O, Gaj P, Lazniewski M, Firczuk M, Borowiec K, Sas-Nowosielska H, Bajor M, Malinowska A, Muchowicz A, Ramji K, Stawinski P, Sobczak M, Pilch Z, Rodziewicz-Lurzynska A, Zajac M, Giannopoulos K, Juszczynski P, Basak GW, Plewczynski D, Ploski R, Golab J, Nowis D.

Haematologica. 2018 Jul 12
 

FOXO1 promotes resistance of non-Hodgkin lymphomas to anti-CD20-based therapy.

Pyrzynska B, Dwojak M, Zerrouqi A, Morlino G, Zapala P, Miazek N, Zagozdzon A, Bojarczuk K, Bobrowicz M, Siernicka M, Machnicki MM, Gobessi S, Barankiewicz J, Lech-Maranda E, Efremov DG, Juszczynski P, Calado D, Golab J, Winiarska M.

Oncoimmunology. 2018 Jan 25

https://www.ncbi.nlm.nih.gov/pubmed/29721381

 

Inhibition of autophagy sensitizes cancer cells to Photofrin-based photodynamic therapy.

Domagala A, Stachura J, Gabrysiak M, Muchowicz A, Zagozdzon R, Golab J, Firczuk M.

BMC Cancer. 2018 Feb 20

https://www.ncbi.nlm.nih.gov/pubmed/29463237

 

Intrinsic Functional Potential of NK-Cell Subsets Constrains Retargeting Driven by Chimeric Antigen Receptors.

Oei VYS, Siernicka M, Graczyk-Jarzynka A, Hoel HJ, Yang W, Palacios D, Almåsbak H, Bajor M, Clement D, Brandt L, Önfelt B, Goodridge J, Winiarska M, Zagozdzon R, Olweus J, Kyte J, Malmberg KJ.

Cancer Immunol Res. 2018 Feb 19

https://www.ncbi.nlm.nih.gov/pubmed/29459477

 

Application of Genome Editing Techniques in Immunology.

Zych A, Bajor M, Zagozdzon R.

Arch Immunol Ther Exp (Warsz). 2018 Jan 17

https://www.ncbi.nlm.nih.gov/pubmed/29344676

 

Targeting Acidic Mammalian chitinase Is Effective in Animal Model of Asthma.

Mazur M, Olczak J, Olejniczak S, Koralewski R, Czestkowski W, Jedrzejczak A, Golab J, Dzwonek K, Dymek B, Sklepkiewicz PL, Zagozdzon A, Noonan T, Mahboubi K, Conway B, Sheeler R, Beckett P, Hungerford WM, Podjarny A, Mitschler A, Cousido-Siah A, Fadel F, Golebiowski A.

J Med Chem. 2018 Jan 11

https://www.ncbi.nlm.nih.gov/pubmed/29283260

 

Photochemical delivery of bleomycin induces T-cell activation of importance for curative effect and systemic anti-tumor immunity.

Norum OJ, Fremstedal ASV, Weyergang A, Golab J, Berg K.

J Control Release. 2017 Dec 28

https://www.ncbi.nlm.nih.gov/pubmed/29042319

 

Discovery of selective, orally bioavailable inhibitor of mouse chitotriosidase.

Mazur M, Bartoszewicz A, Dymek B, Salamon M, Andryianau G, Kowalski M, Olejniczak S, Matyszewski K, Pluta E, Borek B, Stefaniak F, Zagozdzon A, Mazurkiewicz M, Koralewski R, Czestkowski W, Piotrowicz M, Niedziejko P, Gruza MM, Dzwonek K, Golebiowski A, Golab J, Olczak J.

Bioorg Med Chem Lett. 2017 Dec 22

https://www.ncbi.nlm.nih.gov/pubmed/29292229

 

Oxidative Stress in Kidney Diseases: The Cause or the Consequence?

Krata N, Zagożdżon R, Foroncewicz B, Mucha K.

Arch Immunol Ther Exp (Warsz). 2017 Dec 6

https://www.ncbi.nlm.nih.gov/pubmed/29214330

 

In vivo imaging system for explants analysis-A new approach for assessment of cell transplantation effects in large animal models.

Zarychta-Wiśniewska W, Burdzinska A, Zagozdzon R, Dybowski B, Butrym M, Gajewski Z, Paczek L.

PLoS One. 2017 Sep 20

https://www.ncbi.nlm.nih.gov/pubmed/28931067

 

The non-canonical poly(A) polymerase FAM46C acts as an onco-suppressor in multiple myeloma.

Mroczek S, Chlebowska J, Kuliński TM, Gewartowska O, Gruchota J, Cysewski D, Liudkovska V, Borsuk E, Nowis D, Dziembowski A.

Nat Commun. 2017 Sep 20

https://www.ncbi.nlm.nih.gov/pubmed/28931820

 

Selection of an optimal promoter for gene transfer in normal B cells.

Winiarska M, Nowis D, Firczuk M, Zagozdzon A, Gabrysiak M, Sadowski R, Barankiewicz J, Dwojak M, Golab J.

Mol Med Rep. 2017 Sep 16

https://www.ncbi.nlm.nih.gov/pubmed/28713922

 

Inhibition of lymphangiogenesis impairs antitumour effects of photodynamic therapy and checkpoint inhibitors in mice.

Muchowicz A, Wachowska M, Stachura J, Tonecka K, Gabrysiak M, Wołosz D, Pilch Z, Kilarski WW, Boon L, Klaus TJ, Golab J.

Eur J Cancer. 2017 Sep

https://www.ncbi.nlm.nih.gov/pubmed/28709135

 

HDAC6 inhibition up-regulates CD20 levels and increases the efficacy of anti-CD20 monoclonal antibodies.

Bobrowicz M, Dwojak M, Pyrzynska B, Stachura J, Muchowicz A, Berthel E, Dalla Venezia N, Kozikowski M, Siernicka M, Miazek N, Zapala P, Domagala A, Bojarczuk K, Malenda A, Barankiewicz J, Graczyk-Jarzynka A, Zagozdzon A, Gabrysiak M, Diaz JJ, Karp M, Lech-Maranda E, Firczuk M, Giannopoulos K, Efremov DG, Laurenti L, Baatout D, Frenzel L, Malinowska A, Slabicki M, Zenz T, Zerrouqi A, Golab J, Winiarska M.

Blood. 2017 Aug 22

https://www.ncbi.nlm.nih.gov/pubmed/28830887

 

New insights into redox homeostasis as a therapeutic target in B-cell malignancies.

Graczyk-Jarzynka A, Zagozdzon R, Muchowicz A, Siernicka M, Juszczynski P, Firczuk M.

Curr Opin Hematol. 2017 Jul 24

https://www.ncbi.nlm.nih.gov/pubmed/28402987

 

Iterative Sequencing and Variant Screening (ISVS) as a novel pathogenic mutations search strategy - application for TMPRSS3 mutations screen.

Lechowicz U, Gambin T, Pollak A, Podgorska A, Stawinski P, Franke A, Petersen BS, Firczuk M, Oldak M, Skarzynski H, Ploski R.

Scie Rep. 2017 May 31

https://www.ncbi.nlm.nih.gov/pubmed/28566687

 

The Anatomy of Caprine Female Urethra and Characteristics of Muscle and Bone Marrow Derived Caprine Cells for Autologous Cell Therapy Testing.

Burdzinska A, Dybowski B, Zarychta-Wisniewska W, Kulesza A, Zagozdzon R, Gajewski Z, Paczek L.

Anat Rec (Hoboken). 2017 Mar

https://www.ncbi.nlm.nih.gov/pubmed/27741564

 

Co-delivery of indoleamine 2,3-dioxygenase prevents loss of expression of an antigenic transgene in dystrophic mouse muscles.

Sharma D, Al-Khalidi R, Edgar S, An Q, Wang Y, Young C, Nowis D, Gorecki DC.

Gene Ther. 2017 Feb 24

https://www.ncbi.nlm.nih.gov/pubmed/28004656

 

Dissection of CD20 regulation in lymphoma using RNAi.

Słabicki M, Lee KS, Jethwa A, Sellner L, Sacco F, Walther T, Hüllein J, Dietrich S, Wu B, Lipka DB, Oakes CC, Mamidi S, Pyrzyńska B, Winiarska M, Oleś M, Seifert M, Plass C, Kirschfink M, Mann M, Boettcher M, Golab J, Huber W, Fröhling S, Zenz T.

Leukemia. 2016 Aug 18

http://www.ncbi.nlm.nih.gov/pubmed/27560109

 

BCR signaling inhibitors differ in their ability to overcome Mcl-1-mediated resistance of CLL B cells to ABT-199.
Bojarczuk K, Sasi BK, Gobessi S, Innocenti I, Pozzato G, Laurenti L, Efremov DG.

Blood. 2016 Jun 23

http://www.ncbi.nlm.nih.gov/pubmed/27095788

 

MEK Inhibition Sensitizes Precursor B-Cell Acute Lymphoblastic Leukemia (B-ALL) Cells to Dexamethasone through Modulation of mTOR Activity and Stimulation of Autophagy.
Polak A, Kiliszek P, Sewastianik T, Szydłowski M, Jabłońska E, Białopiotrowicz E, Górniak P, Markowicz S, Nowak E, Grygorowicz MA, Prochorec-Sobieszek M, Nowis D, Gołąb J, Giebel S, Lech-Marańda E, Warzocha K, Juszczyński P.

PLoS One. 2016 May 19

http://www.ncbi.nlm.nih.gov/pubmed/27196001

 

The dual role of tumor lymphatic vessels in dissemination of metastases and immune response development.

Stachura J, Wachowska M, Kilarski WW, Güç E, Golab J, Muchowicz A.

Oncoimmunology. 2016 May 13

http://www.ncbi.nlm.nih.gov/pubmed/27622039

 

An Interplay of S-Nitrosylation and Metal Ion Binding for Astrocytic S100B Protein.
Bajor M, Zaręba-Kozioł M, Zhukova L, Goryca K, Poznański J, Wysłouch-Cieszyńska A.

PLoS One. 2016 May 9

http://www.ncbi.nlm.nih.gov/pubmed/27159591

 

Low dose of GRP78-targeting subtilase cytotoxin improves the efficacy of photodynamic therapy in vivo.
Gabrysiak M, Wachowska M, Barankiewicz J, Pilch Z, Ratajska A, Skrzypek E, Winiarska M, Domagala A, Rygiel TP, Jozkowicz A, Boon L, Golab J, Firczuk M.

Oncol Rep. 2016 Apr 1

http://www.ncbi.nlm.nih.gov/pubmed/27035643

 

Investigation of cell death mechanisms in human lymphatic endothelial cells undergoing photodynamic therapy.
Wachowska M, Osiak A, Muchowicz A, Gabrysiak M, Domagała A, Kilarski WW, Golab J.

PhotodiagnosisPhotodynTher. 2016 Feb 8.

http://www.ncbi.nlm.nih.gov/pubmed/26868051

 

Dimeric peroxiredoxins are druggable targets in human Burkitt lymphoma.
Trzeciecka A, Klossowski S, Bajor M, Zagozdzon R, Gaj P, Muchowicz A, Malinowska A, Czerwoniec A, Barankiewicz J, Domagala A, Chlebowska J, Prochorec-Sobieszek M, Winiarska M, Ostaszewski R, Gwizdalska I, Golab J, Nowis D, Firczuk M.

Oncotarget. 2016 Jan 12;7(2):1717-31. doi: 10.18632/oncotarget.6435.

http://www.ncbi.nlm.nih.gov/pubmed/26636537/

 

 

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