The STREAM project was accomplished on December 31, 2018. Initiated in 2016, the three-year project was a joint effort between the Medical University of Warsaw, the University of Oxford, the Francis Crick Institute, Oslo University Hospital and the International Centre for Genetic Engineering and Biotechnology.
Members of the STREAM project have recently published a scientific article in the journal Redox biology (IF = 7,126), which describes a new pro-oxidative strategy of killing cancer cells.
During 3-month long twinning visit (06.09-29.11.2018), Mieszko Lachota, Medical University of Warsaw student and STREAM member was working with a team of Prof. Karl-Johan Malmberg in the laboratory of the Oslo University Hospital.
In the new article, members of the STREAM project described how cancer genetics influences the efficacy of current immunotherapies.
Authors of the article: Dr Beata Pyrzynska, Dr Malgorzata Firczuk, Prof. Jakub Golab, Dr Abdessamad Zerrouqi explain why most patients fail to experience complete tumor regressions after immunotherapy. Members of the STREAM project summarize that a precise list of frequently mutated genes that govern interactions between cancer and immune cells in immunotherapy-resistant patients would be of clinical value.
In the previous texts published in our knowledge base, members of STREAM project wrote about
immune checkpoint blockade in cancer treatment, immunotherapy with monoclonal antibodies or STING protein.
To find out more information, please visit our website: http://www.stream.wum.edu.pl/en/knowledge-base/189-cancer-genetics-influences-efficacy-of-current-immunotherapies
