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Project Coordinator

godlo

The project STREAM is coordinated by the Medical University of Warsaw (MUW). MUW is one of the oldest and most prominent medical schools in Poland. Aside from its educational mission, MUW is a very competitive research centre. It has managed to establish a recognized international position in research, both in clinical and theoretical medicine. Recently MUW was a coordinator of 5.5M euro project entitled “From basic to translational oncology” (acronym: BASTION, project coordinator – prof. Jakub Golab) in a 7th Framework Programme (FP7) Capacities call (http://bastion.wum.edu.pl/). BASTION significantly contributed to build MUW’s capacity as a leading Central European research centre in basic and translational oncology through hiring new staff, exchange of know-how and scientific expertise and investment in cutting edge research equipment. MUW is also a coordinator of the 100M euro Centre of Preclinical Research and Technology (CePT) investment project funded from the European Structural Funds (https://cept.wum.edu.pl). These major capacity building activities ensure access to excellent human capital and research infrastructure for the innovation and development program.


Jakub GolabProf. Jakub Gołąb graduated from the Faculty of Medicine, Medical University of Warsaw in 1998. He obtained his Ph.D. in 1999 in the Institute of Biostructure Research, MUW. He had postdoctoral trainings in Harvard Institutes of Medicine (1999-2000) and University of Texas Southwestern Medical School (2003). Since 2009, Prof. Jakub Golab heads the Department of Immunology at MUW, supervising the team of young group leaders who dedicated their careers to the basic and translational research in Immuno-Oncology. Prof. Golab has also been active in privately funded drug development initiatives.

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Prof. Golab’s major area of expertise is tumour immunology. His research concentrates on anti-tumour therapies and strategies to improve immune response against tumour cells. His major long-term goal is the development of diagnostic and therapeutic methods customized to patients’ individual needs.


Beata PyrzynskaDr Beata Pyrzynska graduated from the Warsaw University with MSc degree in biology. As a Ph.D student at the Nencki Institute of Experimental Biology in Warsaw she was awarded by the Foundation for Polish Science (FNP) with the START fellowship for young outstanding scientists. She also received a short-term fellowship from EMBO to collaborate with the National Center of Biotechnology (CNB) in Madrid. Her Ph.D. thesis dissertation (2001) was awarded at the Nencki Institute of Experimental Biology. In 2002 Dr. Pyrzynska was recruited to the Winship Cancer Institute, Emory University, Atlanta, USA, to work as a postdoctoral fellow in the Laboratory of Molecular Neuro-Oncology.

Her work was awarded with the research fellowships from NATO and from the American Brain Tumor Association (ABTA). In 2006 Dr. Pyrzynska returned to Poland to work at the International Institute of Molecular and Cell Biology (IIMCB) in Warsaw. She studied the signal transduction pathways originated at the endocytic compartments and influencing different aspects of tumor growth. In 2013 she was recruited as an experienced scientist to the BASTION project, coordinated by the Department of Immunology, Medical University of Warsaw (MUW).

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Over the years Dr Pyrzynska has conducted the research in cancer biology and cancer therapeutics field. She studied the regulation of cellular signaling leading to changes in gene expression and tumorigenesis. Currently her research aims to elucidate mechanisms of regulation of CD20 expression, a surface molecule used as target for therapeutic monoclonal antibodies eliminating malignant B cells. Her research is supported by National Science Centre (NCN, Poland) with grant OPUS (“Influence of AKT signaling pathway on CD20 expression and antitumor activity of therapeutic monoclonal antibodies”, 2014-2017, Principal Investigator: B. Pyrzynska). Dr Pyrzynska is also a supervisor of a project funded by the Ministry of Science and Higher Education (Diamond Grant, “Influence of selected chemotherapeutics on efficacy of anti-CD20 immunotherapy”, 2016-2018, Principal Investigator: N. B. Miazek).


Magda WiniarskaDr Magdalena Winiarska graduated from the Faculty of Pharmacy, MUW in 2002. She received her doctoral degree in 2008 from the Center of Biostructure, MUW. She worked in the Department of Immunology as a postdoctoral fellow within the TEAM project (2009-2012). Currently, Dr.Winiarska works as an assistant professor at the Department of Immunology, MUW, where she is leading her own research group. Dr. Winiarska served as a Principal Investigator in 5 research projects (and a supervisor of 3 PhD projects funded by Ministry of Science and Higher Education and National Science Center.

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In the course of her work Dr.Magdalena Winiarska endeavors to improve and ‘tailor’ therapies incorporating monoclonal antibodies. Her research is focused on molecular mechanisms of antitumor effects of anti-CD20 monoclonal antibodies. The aim of her research is to identify new key modulators responsible for resistance to anti-CD20 monoclonal antibody-based therapeutic modalities.


Radek ZagozdzonDr Radosław Zagozdzon graduated from the Faculty of Medicine, Medical University of Warsaw in 1996. He received his doctoral degree in medical sciences in 1998 from the Institute of Biostructure Research, MUW. In the years 1997‒2000, he worked as a physician in the Department of Immunology, Transplantology and Internal Medicine, Transplantation Institute, MUW. In 1999, he received the first degree of specialization in internal medicine. In the years 1999‒2000, he worked as an assistant professor in the Department of Immunology, MUW. In the years 2000‒2005, he was employed as a postdoctoral fellow and, subsequently, (2005‒2008) an instructor in medicine in Beth Israel Deaconess Medical Center, a teaching hospital of Harvard Medical School in Boston, USA.

In the years 2008-2012, he worked as a postdoctoral fellow/occasional lecturer at University College Dublin in Ireland. In 2012-2015 he worked as the leader of the research group in the BASTION project (funded under FP7 by the European Union) and then as a leader of the research project (granted by the National Science Centre) in the Department of Immunology, the Medical University of Warsaw, by the end of 2016. Currently, he is the head of the Department of Clinical Immunology of the Institute of Transplantation, the Medical University of Warsaw and, since 2015, a scientific consultant in the Department of Bioinformatics Institute of Biochemistry and Biophysics.

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Dr. Zagozdzon works in the field of experimental oncology, tumor immunology and immunotherapy. He is mainly focused on investigation of redox homeostasis in tumor and immune cells, in particular NK cells. The aim of his research is to better understand the function of particular antioxidant enzymes in cell survival and growth-promotion, tumor resistance to chemotherapy-induced cell death and immune escape.


Gosia FirczukDr Małgorzata Firczuk graduated from the Intercollegiate Faculty of Biotechnology, University of Gdansk and Medical University of Gdansk in 2002 and from Faculty of Pharmacy, Medical University of Gdansk in 2003. She performed her PhD studies in the International Institute of Molecular and Cellular Biology in Warsaw and received her doctoral degree in biological sciences in 2007. In the years 2007-2009 she continued her work as a postdoctoral fellow in the International Institute of Molecular and Cellular Biology. In 2009 she moved to the Department of Immunology, Medical University of Warsaw, where she worked within the TEAM project (2009-2012) and then within BASTION project (2013-2015). Currently, she is building her own Group at the Department of Immunology, MUW.

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Dr Firczuk research is focused on better understanding of lymphoma and leukemia biology, in particular the role of antioxidant enzymes, and their interplay with key signaling pathways in malignant B cells. She studies the role of selected antioxidant enzymes in the context of their therapeutic targeting. Her long-term goal is the development of novel therapeutic approaches or more effective drug combinations for the treatment of B cell derived malignancies.

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